In a general hospital near bankruptcy, the reduced staff is working under a severe stress. During the emergency attendance to a burned patient with Dr. Uozumi (Masanobu Takashima) and two other nurses, Dr. Akiba (Kôichi Satô) and the nurse commit an error, injecting sodium chlorate and killing him. Dr. Uozumi convinces the team to forge the report to save their careers. Meanwhile, an ambulance leaves a patient in the emergency with a lethal infection. When the muscles and internal organs of the patient liquefy, Dr. Kiyoshi Akai (Shirô Sano) convinces his two colleagues to examine and research the virus, leading the employees of the night shift to a tragic end.

Japan, 250 years ago. Soetsu is a moneylender who is killed by the cruel samurai Shinzaemon. His body is dumped in the Kasenega-Fuchi river. According to legend, all who drown in the river will never surface again. 20 Years later, Shinkichi, the handsome son of Shinzaemon, coincidentally meets Toyoshiga, the daughter of Soetsu. They fall in love. It is a doomed love, as the spirit of Soetsu is far from dead.